Table 2.
Age‐Adjusted Mortality Rate Trend in US Subjects With Heart Failure and Atrial Fibrillation, 1999 to 2020, Stratified by Age
| AAMR 1999 (95% CI) | AAMR 2020 (95% CI) | AAPC; (95% CI), P | Number of joinpoints | Period 1 [y]; APC (95% CI); P value | APC period 2 [y]; APC (95% CI); P value | P (for parallelism) | |
|---|---|---|---|---|---|---|---|
| <65 y (all) | 0.23 (0.21–0.25) | 1.32 (1.28–1.36) | +7.5 (6.7–8.4); <0.001 | 1 | [1999–2010]; +3.9 (2.8–5.1); <0.001 | [2010–2020]; +11.6 (10.2–13.0); <0.001 | … |
| Men | 0.33 (0.11–0.15) | 1.89 (1.83–1.96) | +8.1 (7.4–8.7); <0.001 | 1 | [1999–2010]; +4.7 (3.8–5.6), P<0.001 | [2010–2020]; +11.9 (10.7–13.1), P<0.001 | 0.46 |
| Women | 0.13 (0.11–0.15) | 0.75 (0.71–0.79) | +7.5 (6.3–8.6);<0.001 | 1 | [1999–2009]; +3.7 (1.9–5.6); <0.001 | [2009–2020]; +11.0 (9.3–12.7); <0.001 | |
| ≥65 y (all) | 62.93 (62.09–63.77) | 152.90 (151.84–153.96) | +4.0 (3.7–4.3); <0.001 | 1 | [1999–2011]; +2.1 (1.7–2.4); <0.001 | [2011–2020]; +6.6 (6.0–7.2); <0.001 | … |
| Men | 66.03 (64.54–67.53) | 181.05 (179.23–182.88) | +4.6 (4.2–4.9); <0.001 | 1 |
[1999–2011]; +2.5 (2.1–2.9); <0.001 |
[2011–2020]; +7.4 (6.8–8.1);<0.001 | <0.001 |
| Women | 60.46 (59.45–61.48) | 132.26 (130.98–133.54) | +3.5 (3.1–3.8); <0.001 | 1 | [1999–2011]; +1.7 (1.3–2.2); <0.001 | [2011–2020]; +5.8 (5.1–6.5); <0.001 |
AAMR indicates age‐adjusted mortality rate, expressed as deaths per 100 000 population; AAPC, average annual percent change; and APC, annual percent change.