Table 5.

The Impact of Cumulative Dose Before and After the RCS Turning Point on Osteoporosis

Osteoporosis	OR (95% CI)	P value
Turning point (mg.months)	400
Cumulative dose < 400 mg.months	Reference
Cumulative dose > = 400 mg.months	0.337 (0.204, 0.543)	<0.001

Notes: Age, sex, BMI, smoking status, serum potassium, PTH, serum calcium, serum phosphorus, ALP, and the use probability of spironolactone were adjusted.

Abbreviations: RCS, restricted cubic splines; OR, odds ratio; CI, confidence interval; BMI, body mass index; PTH, parathyroid hormone; ALP, alkaline phosphatase.