Table 2.
Baseline levels on test days. Baseline levels (mean of t = −10 and t = −5 minutes) of CTX, P1NP, PTH, sclerostin, insulin, C-peptide, glucose, heart rate, systolic and diastolic blood pressure
| Placebo | GIP | GLP-2 | P-value of rm one-way ANOVA | |
|---|---|---|---|---|
| CTX (ng/mL) | 0.19 ± 0.096 | 0.19 ± 0.097 | 0.19 ± 0.10 | 0.90 |
| P1NP (ng/mL) | 37 ± 3.4 | 36 ± 3.2 | 37 ± 3.2 | 0.13 |
| PTH (pg/mL) | 41 ± 4.2 | 37 ± 2.7 | 35 ± 2.8 | 0.23 |
| Sclerostin (ng/mL) | 0.78 ± 0.088 | 0.79 ± 0.10 | 0.77 ± 0.11 | 0.94 |
| Insulin (pmol/L) | 81 ± 7.4 | 79 ± 9.7 | 78 ± 10.2 | 0.86 |
| C-peptide (pmol/L) | 670 ± 39 | 637 ± 46 | 624 ± 42 | 0.06 |
| Glucose (mmol/L) | 8.5 ± 0.36 | 8.7 ± 0.37 | 8.4 ± 0.35 | 0.67 |
| Heart rate (bmp) | 63 ± 3.6 | 65 ± 3.5 | 66 ± 4.5 | 0.38 |
| Systolic blood pressure (mmHg) | 140 ± 4.80 | 136 ± 5.73 | 139 ± 5.87 | 0.54 |
| Diastolic blood pressure (mmHg) | 85.9 ± 2.41 | 83.0 ± 2.49 | 84.5 ± 3.01 | 0.25 |
Abbreviations: CTX, C-terminal telopeptide; GIP, glucose-dependent insulinotropic polypeptide; GLP-2, glucagon-like peptide-2; P1NP, procollagen type 1 N-terminal propeptide; rm, repeated measures.
Data are shown as mean ± SEM. Differences between groups are analyzed by rm one-way ANOVA with Geisser–Greenhouse correction and Holm–Sidak multiple comparison tests between all test days.