Table 7.

Signs and symptoms of glucocorticoid-induced (exogenous) cushing syndrome

Symptoms	Muscle weakness Sleep disturbances (insomnia) Increased appetite Mood and cognitive disturbances (irritability, impaired memory, depression)
Signs	Proximal muscle weakness and wasting Excess weight gain and central obesity Supraclavicular and dorsocervical fat accumulation Facial and upper neck plethora with facial rounding Skin atrophy with easy bruising, red stretchmarks, and poor wound healing Acne Menstrual irregularities in women
Other manifestations	Cardiometabolic risk factors (hypertension, dysglycemia, dyslipidemia, hypercoagulability) Osteoporosis and fragility fractures Hypogonadism, reduced libido, and reduced fertility