Table 2.

Summary of some researches on the use of EVs detection for pancreatic cancer diagnosis.

Target	Method	Technology	Experiment objective	AUC	Ref.
exoDNA	KRAS	ddPCR	Compare exoDNA to ctDNA in liquid biopsies	/	(50)
exoDNA	Pancreas-­specific methylation	Whole genome bisulfite sequencing	Distinguish between early PDAC and normal	0.95	(24)
miRNA	ExmiR-191	RT-qPCR	Diagnosing PC	0.79	(44)
miRNA	ExmiR-21	RT-qPCR	Diagnosing PC	0.83	(44)
miRNA	ExmiR-451a	RT-qPCR	Diagnosing PC	0.76	(44)
Cell surface markers	GPC1	Flow cytometry	Differentiate between pancreatic cancer, benign pancreatic disease and normal	1.00	(46)
Cell surface markers	GPC1 and CD63	Integrated analysis of exosomal protein on alternating current electrokinetic chips	Distinguish between PDAC and normal	1.00	(47)
Cell surface markers	GPC1	Graphene Sensor Arrays	Distinguish between PDAC and normal	/	(48)