Figure 6.

Examples of how dysregulated inflammatory molecules could play a pathological role in ME/CFS (113, 137, 225, 231, 235–247). Molecules highlighted in red represent pro-inflammatory molecules, whereas those written in green represent anti-inflammatory molecules. Created with Biorender.com. COX-2, cyclooxygenase-2; IL, interleukin; ME/CFS, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; NK, natural killer; PBMC, peripheral blood mononuclear cell; PGE2, prostaglandin-endoperoxide synthase 2; TGF-β, transforming growth factor-β; TNF-α, tumour necrosis factor-α; Treg, regulatory T cell; VEGF, vascular endothelial growth factor.