FIGURE 1.

Multivariable‐adjusted absolute risk of dementia during the course of the study and corresponding relative risks (HR)^a according to increasing levels of LIBRA score and genetic risk (N = 5170). ^a Relative risks (HR, as presented in tables) were estimated with cause‐specific Cox models censoring at death. The timescale was the delay between the date of inclusion and either the date of dementia, death, or the end of follow‐up, whichever came first. Absolute risks of dementia (as presented in plots) were estimated from the cause‐specific Cox model while accounting for competing risk by death by specifying a cause‐specific Cox model for death before dementia. All Cox models used baseline hazard rates stratified by study center and included: the LIBRA score (continuous), the genetic factor (APOE ε4 status in panel A, dementia GRS [tertiles] in panel B), the interactions of LIBRA score and the genetic factor, and covariates (age, sex, education level, income, genetic ancestry, and APOE ε4 status in panel B). The P value for LIBRA x GRS interaction test as embedded in (B) plot was estimated in a distinct model considering the GRS continuously. Curves represent the absolute risk of dementia at each time of follow‐up of an average study participant profile (a woman from the Bordeaux site, aged 74 years old at inclusion with educational level equal to middle school and monthly income between 1500 and 2250€). Note that the choice of profile is made to optimize the graphical representation and has no influence on the differences in HR estimated by the model (calculated for each increase of one point of LIBRA taken as a continuous variable). We chose two representative levels of LIBRA score (lower level = upper bound of the first quartile and higher level = lower bound of the fourth quartile), stratified in two levels of genetic factor (APOE ε4 carrier vs. no carrier in [A], and first tertile [low] vs. third tertile of GRS [high]). APOE, apolipoprotein E; CI, confidence interval; GRS, genetic risk score; HR, hazard ratio; LIBRA, LIfestyle for BRAin health risk score