TABLE 2.
Baseline characteristics of participants according to increasing levels of LIfestyle for BRAin health risk (LIBRA) score (N = 5170).
| LIBRA score a | |||
|---|---|---|---|
| Low [−5.9; −1.0] | Intermediate [−1; 2.7] | High [2.7; 11.2] | |
| (n = 1383) | (n = 2503) | (n = 1284) | |
| Study center, N (%) | |||
| Bordeaux | 248 (17.9) | 578 (23.1) | 339 (26.4) |
| Dijon | 957 (69.2) | 1646 (65.8) | 836 (65.1) |
| Montpellier | 178 (12.9) | 279 (11.1) | 109 (8.5) |
| Sociodemographic characteristics | |||
| Age, mean (SD), years | 73.1 (5.0) | 73.7 (5.2) | 74.8 (5.4) |
| Women, N (%) | 936 (67.7) | 1485 (59.3) | 751 (58.5) |
| Education ≥ secondary school, N (%) | 724 (52.4) | 918 (36.7) | 354 (27.6) |
| Monthly income ≥ 1500€, N (%) | 966 (71.7) | 1464 (60.7) | 647 (52.1) |
| LIBRA score, mean (SD) | –2.43 (1.25) | 1.02 (0.97) | 4.29 (1.24) |
| Lifestyle and health characteristics (LIBRA components) | |||
| Healthy diet, N (%) | 520 (37.6) | 437 (17.5) | 74 (5.8) |
| Physical inactivity, N (%) | 98 (7.1) | 654 (26.1) | 562 (43.8) |
| Engagement in cognitively stimulating activities, N (%) | 1046 (75.6) | 525 (21.0) | 41 (3.2) |
| Alcohol consumption (> 0 and < 14 units of alcohol per week), N (%) | 973 (70.4) | 1171 (46.8) | 447 (34.8) |
| Current smoking, N (%) | 31 (2.2) | 113 (4.5) | 128 (9.9) |
| Heart disease, N (%) | 31 (2.2) | 213 (8.5) | 212 (16.5) |
| Diabetes, N (%) | 30 (2.2) | 179 (7.2) | 247 (19.2) |
| High cholesterol, N (%) | 399 (28.9) | 896 (35.8) | 694 (54.0) |
| Body mass index, mean (SD), kg/m2 | 24.7 (3.4) | 25.5 (3.8) | 27.5 (4.6) |
| Hypertension, N (%) | 950 (68.7) | 1913 (76.4) | 1181 (92.0) |
| Renal dysfunction, N (%) | 63 (4.6) | 248 (9.9) | 324 (25.2) |
| Depressive symptomatology, N (%) | 33 (2.4) | 209 (8.3) | 375 (29.2) |
| Genetic characteristics | |||
| APOE ε4 carrier, N (%) | 276 (20.0) | 495 (19.8) | 268 (20.9) |
| Genetic risk score b , N (%) | |||
| Low | 494 (35.7) | 817 (32.6) | 413 (32.2) |
| Medium | 443 (32.0) | 865 (34.6) | 415 (32.3) |
| High | 446 (32.2) | 821 (32.8) | 456 (35.5) |
Abbreviations: APOE, apolipoprotein E; SD, standard deviation.
a
Low, intermediate, and high LIBRA risk score categories were defined as the first quartile, second and third quartiles, and fourth quartile of the score, respectively. LIBRA ranges theoretically from −5.9 to +12.7.
b
Low, medium, and high genetic risk score categories were defined as the first, second, and third tertiles of the score, respectively.