TABLE 3.
Incidence rates of dementia according to increasing levels of LIfestyle for BRAin health risk (LIBRA) score and genetic risk (N = 5170).
| Overall population | LIBRA score a | |||
|---|---|---|---|---|
| Low | Intermediate | High | ||
| Overall population |
652/5170 1.5 (1.4–1.6) |
132/1383 1.1 (0.9–1.2) |
297/2503 1.4 (1.2–1.6) |
223/1284 2.3 (2.0–2.7) |
| APOE ε4 carrier status | ||||
| Non‐carrier | 479/4131 | 99/1107 | 215/2008 | 165/1016 |
| 1.4 (1.2–1.5) | 1.0 (0.8–1.2) | 1.2 (1.1–1.4) | 2.1 (1.8–2.5) | |
| Carrier | 173/1039 | 33/276 | 82/495 | 58/268 |
| 2.1 (1.8–2.5) | 1.4 (1.0–1.9) | 2.1 (1.6–2.5) | 3.3 (2.5–4.3) | |
| GRS b | ||||
| Low | 187/1724 | 44/494 | 85/817 | 58/413 |
| 1.3 (1.1–1.5) | 1.0 (0.7–1.3) | 1.2 (1–1.5) | 1.9 (1.4–2.4) | |
| Medium | 212/1723 | 41/443 | 96/865 | 75/415 |
| 1.5 (1.3–1.7) | 1.0 (0.7–1.4) | 1.4 (1.1–1.7) | 2.2 (1.7–2.7) | |
| High | 253/1723 | 47/446 | 116/821 | 90/456 |
| 1.8 (1.6–2.0) | 1.2 (0.9–1.6) | 1.6 (1.3–1.9) | 3.0 (2.4–3.7) | |
Abbreviations: APOE, apolipoprotein E; CI, confidence interval; GRS, genetic risk score.
Note: Data are number of incident cases/total and incidence rate per 100 person‐year (95% CI).
a
Low, intermediate, and high LIBRA risk score categories were defined as the first quartile, second and third quartiles, and fourth quartile of the score, respectively.
b
Low, medium, and high genetic risk score categories were defined as the first, second, and third tertiles of the score, respectively.