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. 2024 May 15;20(6):4185–4198. doi: 10.1002/alz.13871

TABLE 1.

Demographics and clinical information in SS‐OCTA cohort.

SS‐OCTA Controls (n = 31) EOAD (n = 37) P value
Age, years 64.0 ± 5.8 62.2 ± 5.9 0.191
Female, n (%) 19 (61.3%) 15 (40.5%) 0.144
Hypertension, n (%) 11 (35.5%) 13 (35.1%) 1.000
Diabetes, n (%) 7 (22.6%) 6 (16.2%) 0.722
Dyslipidemia, n (%) 3 (9.7%) 6 (16.7%) 0.633
Education, years 9.0 (6.0–12.0) 6.0 (6.0–9.0) 0.063
MoCA Score 28.0 (26.0–29.0) 10.0 (6.0–15.0) <0.001
Total volume + CSF, cm3 1443 (1368–1593) 1441 (1311–1524) 0.040
Total volume, cm3 1136 (1071–1186) 1085 (990–1129) <0.001
Hippocampus, cm3 6.9 (6.7–7.2) 5.3 (4.5–6.3) <0.001
Frontal lobe, cm3 151.6 (147.2–159.6) 145.4 (131.6–157.9) 0.014
Occipital lobe, cm3 68 (66–72) 66 (60–70) 0.027
Temporal lobe, cm3 103.5 (99.0–112.9) 92.4 (85.2–98.1) <0.001
Parietal lobe, cm3 73.1 (71.0–76.1) 70.7 (62.1–75.0) 0.040
Aβ40, pg/mL 52.6 (41.8–82.0) 91.1 (55.4–106.4) 0.031
Aβ42, pg/mL 4.52 (1.28–5.73) 8.25 (6.36–9.55) 0.026
Aβ42/40 0.070 (0.040–0.094) 0.080 (0.070–0.110) 0.057
Tau, pg/mL 0.70 (0.43–0.82) 0.64 (0.42–0.94) 0.763
p‐tau181, pg/mL 0.30 (0.20–0.61) 1.51 (0.89–2.55) <0.001
SVP, mm2 1.28 ± 0.08 1.20 ± 0.20 0.002
ICP, mm2 1.00 ± 0.07 0.91 ± 0.20 0.001
DCP, mm2 0.86 ± 0.06 0.72 ± 0.16 <0.001
Choriocapillaris, mm2 2.83 ± 0.08 2.53 ± 0.24 <0.001

Note: Data were expressed as mean (standard deviation) or frequency (%) as appropriate.

Abbreviations: Aβ, amyloid beta; CSF, cerebrospinal fluid; DCP, deep capillary plexus; EOAD, early‐onset Alzheimer's disease; HC, healthy controls; ICP, intermediate capillary plexus; IOP, intraocular pressure, measured in millimeters per mercury (mmHg); MMSE, Mini‐Mental State Examination; MoCA, Montreal Cognitive Assessment; p‐tau, phosphorylated tau; SS‐OCTA, swept‐source optical coherence tomography angiography; SVP, superficial vascular plexus.