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. 2024 Jun 3;15:1387945. doi: 10.3389/fimmu.2024.1387945

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Copyright © 2024 Arenas Hoyos, Helmer, Yerly, Lese, Hirsiger, Zhang, Casoni, Garcia, Petrucci, Hammer, Duckova, Banz, Montani, Constantinescu, Vögelin, Bordon, Aleandri, Prost, Taddeo, Luciani, Rieben, Sorvillo and Olariu

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Local TGMS-TAC injections result in higher concentrations of the drug in grafts. (A) Comparison of TAC tissue levels in grafts and contralateral side skin for both single administration of TGMS-TAC (left), and multiple administration TGMS-TAC (R) (right). TAC levels were measured in skin biopsies collected on different postoperative days (POD). Tissue concentrations are represented as ng of TAC per g of skin. (B) Whole-blood levels of tacrolimus in pigs from the TGMS-TAC and (TGMS-TAC (R) groups were measured at POD 0, 1, 3, and then on a weekly basis. Blood levels are expressed as ng/ml. TGMS-TAC injection time points are indicated with a syringe. TAC was measured in both skin and whole blood using LC-MS/MS. Data are represented as means ± SD of n=4 samples.