TABLE 1.

Population characteristics.

	AD cases	Age‐matched controls	Cognitively healthy centenarians
Sample size	2281	3165	346
Age	67.96 ± 9.84	62.57 ± 8.66	101.05 ± 2.51
Females (%)	1265 (55%)	1507 (48%)	247 (71%)
APOE ε2 (%)	3%	9%	13%
APOE ε4 (%)	43%	17%	7%

Note: Additional information about the cohorts used is available in Methods and Supplementary Methods (in supporting information) sections. Reference to the cohorts described in this table are: Holstege et al., ⁵ van der Flier and Scheltens, ¹⁷ Rademaker et al., ²⁰ Hoogendijk et al.,²¹ Willemsen et al., ²² and Slot et al. ²⁹ Age = age at onset for AD cases, age at study inclusion for age‐matched controls, and cognitively healthy centenarians.

Abbreviations: AD, Alzheimer's disease; APOE, apolipoprotein E.