Supplementary Table 1.

Clinical summary and characteristics of our patient and previously reported patients with PRES-associated PLEDs

Patient	Age (years)	Sex	Brain MRI involvement	EEG	Accompanying disorder/Etiology	Seizure type(s)	Treatment (and ASMs)	Follow-up EEG (time)	Outcome
Fitzpatrick et al. ⁶	ND	ND	Bilateral involvement (details ND)	PLEDs (details ND)	Hypertension	ND	ND	ND	ND
Fitzpatrick et al. ⁶	ND	ND	Bilateral involvement (details ND)	PLEDs (details ND)	Hypertension	ND	ND	ND	ND
Bhatt et al. ⁷	47	F	Bilateral temporo-occipital lobes	PLEDs (details ND)	Non-small cell carcinoma of the lung on etoposide treatment	No seizure	Discontinuation of etoposide	Normal (10th day)	Good (seizure free)
Skiba et al. ⁸	28	M	Bilateral parieto-occipital lobes	Posteriorly dominant bilateral PLEDs, slowing of the posterior background rhythm	Thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, hypertension, chronic renal failure	Generalized tonic-clonic, focal-nonmotor-sensory	Intravenous antihypertensives, valproic acid, phenytoin and levetiracetam	Normal (time ND)	Recurring several generalized tonic-clonic seizures
Kastrup et al. ⁴	60	F	Bilateral frontal, temporal and parieto-occipital lobes	Left dominant bilateral PLEDs, slowing of the posterior background rhythm	Facioscapulohumeral dystrophy, electrolyte imbalance	Generalized and focal motor	Correction of electrolyte imbalance, clonazepam, valproic acid	Normal (21th day)	Good (seizure free)
Choi et al. ⁹	54	F	Unilateral medial temporal, parieto-occipital lobes	Posteriorly dominant unilateral PLEDs, slowing of the posterior background rhythm	Subacute encephalopathy with seizures in alcoholics syndrome	Focal to bilateral tonic-clonic	Levetiracetam	ND	Poor (persisting aphasia and motor weakness)
Cherian et al. ¹⁰	32	F	Bilateral parieto-occipital (left dominant) and frontal lobes	Unilateral (right) occipital PLEDs, slowing of the posterior background rhythm	Crohn’s disease on mesalamine treatment (immunomodulator), pulmonary tuberculosis	Convulsive status epilepticus	Valproic acid	Slowing of the posterior background rhythm (time ND)	Good (seizure free)
Kandemir et al. ¹¹	60	F	Bilateral parieto-occipital lobes	Left dominant bilateral temporo-parieto-occipital PLEDs, slowing of the posterior background rhythm	Metastatic lung cancer, usage of carboplatin and paclitaxel therapy	Generalized tonic-clonic, focal-nonmotor-sensory	Dexamethasone, phenytoin infusion, levetiracetam	Slowing of the background and PLEDs on both temporo-parieto-occipital regions (17th and 50th days)	Recurring seizures, death secondary to cardiopulmonary arrest due to cancer progression
Silveira et al. ¹²	20	F	Bilateral frontal, posterior temporal, and parietooccipital lobes	Unilateral (right) temporo-parieto-occipital PLEDs plus fast activity	Acute intermittent porphyria, hypertension	Generalized tonic-clonic	Antihypertensives, lorazepam, levetirasetam, high dose steroids	ND	Good (seizure free)
Kamiya-Matsuoka et al. ³	Adult (detail ND)	ND	Bilateral posterior parieto-occipital lobes, and thalamus	Left dominant bilateral occipital PLEDs	Malignancy (details ND)	ND	ND	Symmetric generalized rhythmic discharges (time ND)	Poor (details ND)
Subramaniam et al. ¹³	77	M	Left posterior regions	Unilateral (left) posterior PLEDs	ND	ND	Four ASMs (details ND)	ND	ND
Matsumoto et al. ¹⁴	79	F	Unilateral (left) rectal gyrus, temporo-parietal lobes, insular cortex, and thalamus	Unilateral (left) PLEDs	Epilepsy, chronic phase of subarachnoid hemorrhage	Focal motor	Levetiracetam, general anesthesia, valproic acid, perampanel	Normal (time ND)	Poor, (motor and sensory aphasia and right hemispatial neglect, recurring seizures)
Fisher et al. ¹⁵	40	F	Bilateral parieto-occipital and left frontal (with punctate hemorrhages)	Unilateral (right) occipital and posterior temporal PLEDs, focal occipital electrographic seizures	Liver transplant for alcoholic cirrhosis on prednisone, tacrolimus, and mycophenolate for acute rejection, hypertension	Focal-nonmotor-sensory, focal motor, focal to bilateral tonic-clonic	Antihypertensive, levetiracetam, pregabalin, lacosamide, midazolam, propofol, ketamine, topiramate, clobazam, transcranial direct current stimulation	Interictal temporo-occipital spikes (time ND)	Good (seizure free)
Cordelli et al. ¹⁶ (Total six children)	ND	ND	ND	PLEDs (details ND)	ND	ND	ND	ND	ND
Present case	10	F	Left dominant bilateral temporo-parieto-occipital lobes	Left dominant bilateral PLEDs plus fast activity, slowing of the posterior background rhythm	Acute extremity compartment syndrome, hypertension, hyponatremia, hypocalcemia, hypomagnesemia	Focal-nonmotor-sensory, focal motor	Antihypertensive, correction of electrolyte imbalance, levetiracetam, clobazam	Mild unilateral (left) slowing of the posterior background rhythm (6th day)	Good (seizure free)

ASM, antiseizure medication; EEG, electroencephalography; F, female; M, male; MRI, magnetic resonance imaging; ND, not documented; PLEDs, periodic lateralized epileptiform discharges; PRES, posterior reversible encephalopathy syndrome.