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. 2024 May 31;20:1270–1277. doi: 10.3762/bjoc.20.109

Table 1.

Optimization of reaction conditions for the treatment of t-Bu-FIDO with Lawesson's reagent.a

graphic file with name Beilstein_J_Org_Chem-20-1270-i001.jpg
Entry Equiv Reaction temperature (°C) Solvent Reaction time (h) Conversionb (%)
1
2
3
4
5
6
7
8
9
10		 1.5
1.5
1.5
1.5
3
3
14
20
20
20		 70
50
70
100
100
120
120
120
120
120		 THF
CS2
o-DCB
toluene
toluene
toluene
toluene
toluene
toluene
o-DCB		 14
14
14
14
14
14
14
14
20
20		 NRc
NR
NR
NR
5
10
50
70
90
99

aAll reactions were performed with t-Bu-FIDO (50 mg) under N2 atmosphere. All the solvents (10 mL) were anhydrous. bConversion was estimated from the HPLC peak area ratio. cNR = no reaction.