TABLE 5.

Main roles areas for CRNs and their level of deployment the world [Modified of (93)].

CTN roles	CRN involvement (1 to 5 +)
Research teams: central contact, documents, monitor, team education, protocol management	+ + + +
IRB/independent ethics committee and informed consent development: informed consent evaluation, patient education, IRB member	+ + +
Protocol assessment tasks: protocol feasibility, submission, review	+ +
Study participants: informed consent, patient assessment, communication and advocate with participants, scheduling	+ + + + +
Study site management: monitor, documents care, communications, manages and negotiates budget, processing samples	+ + + +