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. 2024 May 23;67(11):9124–9149. doi: 10.1021/acs.jmedchem.4c00268

Scheme 1. Synthesis of Final Compound CPK2.

Scheme 1

Reagents and conditions: (a) (2-Bromoethyl)cyclohexane, potassium tert-butoxide, DMF, 130 °C, overnight; (b) MeOH dry, 3 h, RT then NaBH4, 1 h, RT; (c) benzyl bromide, DIPEA, 100 °C, μW, 20 min.