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. 2024 May 23;67(11):9124–9149. doi: 10.1021/acs.jmedchem.4c00268

Scheme 5. Synthesis of Final Compound CPK18.

Scheme 5

Reagents and conditions: (a) Benzylamine, HOBt, HBTU, DIPEA, DCM/DMF (4/1, v/v), RT, overnight; (b) TFA/DCM (1/3, v/v), triisopropylsilane, 3 h, RT; (c) 4-phenoxybenzaldehyde, MeOH dry, 3 h, RT then NaBH4, 1 h, RT.