Table 2. Investigation of the DEL Cycle C SAR.

^aPotency data based on n ≥ 2 with SEM within 0.2 log unit, unless otherwise stated.

^bLogD measured via shake-flask method in octanol and water at pH = 7.4.

^cLE (kcal mol^–1 heavy atom^–1) = −0.596(ln(IC₅₀/10⁶))/HAC, where IC₅₀ is expressed in μM, LipE = pIC₅₀ – LogD.