Table 3.

Definitions and reporting of bladder cancer recurrence and progression in RCTs with papillary-only tumors. RFS, recurrence-free survival; NMIBC, non-muscle invasive bladder cancer; MIBC, muscle-invasive bladder cancer; PFR, progression-free survival; DFR, disease-free survival

Study ID	RECURRENCE												PROGRESSION
													DEFINITION
	Time to recurrence	RFS	Recurrence rate	2 yr recurence-free rates	3 yr recurence-free rates	Recurrence per year (n)	NMIBC recurrence (pTa,pT1)	Early recurrence (0-2 yrs)	Late recurrence (> 2 yrs)	50 % recurrence-time (days)	Recurrence index/100 patients per month	Recurrence-rate reduction	T-stage	Grade	MIBC	Metastases	Progression rate	Progression rate at the time of first recurrence	Time to progression to MIBC	Time to progression to distant metastasis	5-yr PFR	Progression as the first event included as recurrence?	Progression-free survival
Kaasinen 2000	x		x														x
Bilen 2000	x		x										≥pT2				x					x
Van der Meijden 2001	x	x			x										x	x			x	x
Nomata 2002					x																	NA
Okamura 2002		x				x									x	x
Rajala 2002	x	x																				NA
Kuroda 2004			x	x																		NA
Koga 2004	x		x		x																	NA
Mitsumori 2004		x	x																			NA
Cheng 2005	x	x													x	x			x	x			x
Vijjan 2006	x		x										Ta->T1, T1->MIBC		x
Hinotsu 2006	x		x		x					x			≥pT2		x	x
Barghi 2006		x													x		x
Ojea 2007	x	x	x								x				x	x	x
El-Ghobashy 2007		x	x			x	x		x				≥pT2		x	x
Agrawal 2007			x																			NA
Friedrich 2007		x	x	x	x																	NA
Hendricksen 2008	x	x	x										≥pT2, cis		x	x	x		x	x	x
Berrum-Svennung 2008	x		x												x
Isbarn 2008			x	x	x
Böhle 2009		x	x				x								x							x
Gudjonsson 2009	x	x	x
Järvinen 2009	x		x										≥pT2		x	x	x					x
Seretta 2010	x	x	x	x	x								≥pT2		x		x
Sylvester 2010	x												≥pT2		x	x			x	x		x
De Nunzio 2011		x						x (0-1yrs)	x (> 1yr)			x	≥pT2		x
Di Stasi 2011		x	x										≥pT2		x		x		x	x
Hinotsu 2011		x	x	x									≥pT2	x	x	x		x
Oddens 2013	x		x		5yr DFR								≥pT2, cis			x	x		x	x		x
Huang 2015	x	x	x																			NA
Onishi 2017	x	x			x								not specified	x			x						x
Bijalwan 2017	x		x										Ta->T1	LG->HG			x