Table 3.

Multivariable Cox Regression Analysis for Overall Survival

Factor	HR	95% CI	P-Value
eBM (Yes vs No)	2.52	(1.75 –3.63)	<0.0001
Liver Metastases (Yes vs No)	1.47	(1.01 –2.12)	0.042
Lung Metastases (Yes vs No)	0.91	(0.64 –1.30)	0.610
Lymph Node Only Metastases (Yes vs No)	0.84	(0.56 –1.27)	0.416
De-Novo Metastases (Yes vs No)	0.94	(0.65 –1.36)	0.736
Age	1.00	(0.99 –1.02)	0.982
Sex (Male vs Female)	0.91	(0.66 –1.26)	0.563
Smoking (Yes vs No)	1.21	(0.86 –1.71)	0.267
Upper vs Bladder Primary	0.66	(0.45 –0.95)	0.027
Histology (Urothelial Ca vs. Variant)	0.76	(0.53 –1.10)	0.147
ECOG PS 1 vs 0	1.56	(1.05 –2.32)	0.027
ECOG PS≥2 vs 0	2.33	(1.48 –3.69)	<0.001
ECOG PS Missing	0.89	(0.53 –1.49)	0.662
Initial Treatment: Platinum vs CPI	0.60	(0.42 –0.85)	0.004
Initial Treatment: Other vs CPI	0.85	(0.54 –1.33)	0.474

eBM, early bone metastases; CPI, checkpoint inhibitor; HR, hazard ratio; CI, confidence interval