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. 2024 Jun 14;13(1):2367777. doi: 10.1080/2162402X.2024.2367777

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 2. — CD27/28-CD57+ T cells are more abundant in the peripheral blood of HNSCC patients over age 75. (a) Correlation between percent of CD27/28-CD57+ CD8+ T cells in the peripheral blood versus age. (b) Correlation between percent of CD27/28-CD57+ CD8+ T cells in the tumor versus age. (c) Percent of CD27/28-CD57+ CD8+ T cells in the peripheral blood of patients <age 75 versus ≥age 75. (d) Correlation between percent of CD27/28-CD57+ CD4+ T cells in the peripheral blood versus age. (e) Correlation between percent of CD27/28-CD57+ CD4+ T cells in the tumor versus age. (f) Percent of CD27/28-CD57+ CD4+ T cells in the peripheral blood of patients <age 75 versus ≥age 75. (g, h) Percent of CD27/28-CD57+ CD8+ T cells (G) and CD4+ T cells (h) in the peripheral blood of patients according to disease stage. (i, j) Percent of CD27/28-CD57+ CD8+ T cells (i) and CD4+ T cells (j) in the peripheral blood of patients according to anatomic site. (k, l) Percent of CD27/28-CD57+ CD8+ T cells (k) and CD4+ T cells (l) in the peripheral blood of patients according to sex. (m, n) Percent of CD27/28-CD57+ CD8+ T cells (m) and CD4+ T cells (n) in the peripheral blood of patients according to histopathologic features including perineural invasion (PNI), lymphovascular invasion (LVI) and extracapsular spread (ECS). Box plot whiskers depict min and max. *p < .05 by student’s t test.