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. 2024 Jun 14;13(1):2367777. doi: 10.1080/2162402X.2024.2367777

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — CD27/28-CD57+ T cells are not enriched for markers of senescence. (a, b) Flow cytometry data gated on live CD3+CD8+ (a) and CD3+CD4+ (b) cells from tumor samples of 18 patients ≥ age 75 were concatenated and tSNE plots created. A cluster of CD27/28-CD57+ T cells was identified that was enriched for KLRG1 and granzyme B but not for senescence markers β-galactosidase or p16. (c,d) p16^INK4A (c) and β-galactosidase (d) expression among T cell subsets in the TIL. (e, f) p16^INK4A (e) and β-galactosidase (f) expression among T cell subsets in the peripheral blood. MFI, mean fluorescence intensity.