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. 2024 Jun 14;13(1):2367777. doi: 10.1080/2162402X.2024.2367777

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — CD27/28-CD57+ T cells secrete high amounts of cytolytic enzymes and cytokines upon stimulation. (a) Granzyme B expression among T cell subsets in the peripheral blood (left) and TIL (right). MFI, mean fluorescence intensity. (b) Perforin expression among T cell subsets in the peripheral blood (left) and TIL (right). (c) Representative flow plots showing baseline expression of granzyme B and perforin among CD8+ T cell subsets in the peripheral blood. (d) Box plots for surface CD107a expression among CD8+ T cell subsets in the peripheral blood after no treatment (control) versus treatment with PMA/ionomycin with or without GolgiPlug. (e) Representative flow plots of IFN-γ expression in CD8+ T cell subsets from the peripheral blood treated with PMA/ionomycin with or without GolgiPlug vs. control. (f) Box plots for quantification of IFN-γ expression among CD8+ T cell subsets from the peripheral blood. *p < .05, ***p < .001, ****p < .0001 by two-way ANOVA with post hoc Tukey analyses.