Figure 7.

CD27/28-CD57+ T cells are associated with early locoregional disease relapse in surgically-treated HNSCC. We performed a receiver operating curve (ROC) analysis (a) comparing the proportion of CD8+ T cells in the blood that are CD27/28-CD57+ versus the incidence of locoregional (LR) recurrence within 6 months after surgery. After selecting 34% as the cutoff with 80% sensitivity and specificity for LR recurrence, we then found that patients with > 34% of these cells within the peripheral blood were more likely to have LR disease recurrence within 6 months (b). On Kaplan-Meier analysis, patients with > 34% of these cells within the peripheral blood (red) had significantly lower locoregional disease control (c). AUC, area under the curve; OR, odds ratio.