Dual-sensitive polymer prodrugs based on the combination of endogenous stimuli-sensitive linkers and external stimuli, obtained via the “grafting to” strategy.

External stimuli	Drug	Drug linker	Polymerization method	Nanocarrier	Cleavage conditions	Release	Role of external stimuli	Ref.
Temperature	Dox	Hydrazone	RAFT/ATRP	Alkyne-P(HPMA-st-EGMA)-SS-PNIPAAm	pH 5.5 + GSH 10 mM	80% after 48 h	Micelles formation at 37 °C	179