Stimuli-sensitive drug linkers in polymer prodrugs obtained by RDRP techniques via the “grafting through” strategy.

Linker	Drug	Polymerization method	Polymer prodrug	Cleavage conditions	Release	Ref.
	Dt	RAFT	P(SMA-co-OEGMA)	Human serum	50% after 384 h	185
			P(MAA-co-DMAEMA)-b-PSMA		50% after 240 h
	POD	RAFT	PMA-b-PTEGMA	pH 5	52% after 72 h	188
	20 Cpt: aliphatic ester	RAFT	P(CBM-co-SMA)	Human serum	20 Cpt: 12% after 4 days	211
	10 Cpt: aromatic ester				10 Cpt: 37% after 4 days
	Cpt	RAFT	H40-star-P(MA)-b-PMPC	pH	50% after 36 h	187
	Ibuprofen + Dox	ATRP	PEG-b-PHEMA	pH 5	55% after 10 h	189
	Mtx	RAFT	PHPMA + crosslinker: EGDMA	Esterases	No release	212
	PPMP + Dox	RAFT	POEGMA-b-PMA	PBS	10% after 2 h	215
	Cpt	RAFT	PEG-b-PHSEMA	—	—	195
	Cpt	RAFT	PEG-b-P(EO2MA-co-HSEMA) + cross-linkers: CBMA/BzMA	GSH 10 mM	42% after 48 h	196
	Cpt	RAFT	POEGMA-b-P(POEGMA-co-HSEMA) + cross-linkers: EGDMA/HPMA	GSH 10 mM	70% after 48 h	197
	Cpt	RAFT	h-P(HSEMA-co-GMA)-b-P(OEGMA-co-GPMAAm)	DTT 10 mM	60% after 24 h	147
	Cpt	ATRP	P(HEMA-SS-Cpt)-b-POEGMA	DTT 5 mM	90% after 24 h	203
	Cpt	ATRP	Dex-PHSEMA-b-POEGMA	DTT 10 mM	100% after 72 h	198
	Irinotecan	ATRP	α-CD-P(HSEMA-co-OEGMA)	GSH 10 mM	80% after 120 h	201
	Cpt	ATRP	α-CD-PEG-b-P(HSEMA-b-POEGMA	DTT 10 mM	80% after 24 h	200
	Cpt	RAFT	P(HSEMA-co-PEMA) + PEG-b-PCL	pH 6.8 + GSH 5 mM	50–80% after 50 h	209
	Cpt + Dox	ATRP	α-CD-P(HSEMA-co-OEGMA-co-DPA)	pH 5	Dox: 70% after 72 h	210
				GSH 10 mM	Cpt: 75% after 48 h
	Ptx	RAFT	P(HPMA-co-MAAm)	pH 6 + papain 2 μM	100% after 10 h	217
	Dox	RAFT	P(HPMA-co-MAAm)	—	—	218
	Gem + DACH Pt	RAFT	P(HPMA-co-MAAm)	—	—	219
	Gem + Ptx	RAFT	P(HPMA-co-MAAm)	pH 6 + cathepsin B	Gem: 50% after 30 min	220
					Ptx: 50% after 45 min
	Gem	RAFT	PHPMA	pH 5.4 + cathepsin B	95% after 3 h	221
	Gem	RAFT	P(HEA-co-OEGMA)	pH 5	100% after 20 h	193
	Cpt + Lapa	RAFT	PEG-b-P(MA)	100 mM H2O2 + Fe2+	75% after 48 h	207
	Gem	RAFT	P(SMA)	pH 5 + cathepsin B	70% after 30 days	216