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Proposed model of cell-type specific targeting of p27 by miR-494 in ERM fibrotic transformation. Microglial-mediated inflammation triggers elevations in miR-494 expression in both Müller cells and RPEs, leading to downstream fibrotic transformation in both cell types, and ultimately to ERM formation. Although decreases in p27 play a central role in fibrotic transformation in both cell types, only in RPE cells is reduced expression of p27 due to direct targeting by miR-494.
