TABLE 2.
Summary of flow cytometric data from 4, 8, and 12 weeks after infection of SCID-hu mice with R5-AIDS HIV-1 clone ACH142-*E11, ACH424-23G2, or ACH424-23A1a
| Mouse | Virus | Cell distribution
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 wk
|
8 wk
|
12 wk
|
|||||||||||
| % CD4+ | % CD8+ | % CD4+ CD8+ | CD4+/CD8+ | % CD4+ | % CD8+ | % CD4+ CD8+ | CD4+/CD8+ | %CD4+ | % CD8+ | % CD4+ CD8+ | CD4+/CD8+ | ||
| 24-3 | *E11 | 12 | 7 | 80 | 1.7 | 14 | 10 | 76 | 1.4 | ||||
| 24-5 | 23G2 | 10 | 5 | 85 | 2.0 | 11 | 8 | 80 | 1.4 | ||||
| 24-6 | 23A1 | 16 | 6 | 77 | 2.7 | 12 | 7 | 81 | 1.7 | ||||
| 24-7 | *E11 | 13 | 7 | 79 | 1.9 | 19 | 14 | 31 | 1.4 | ||||
| 24-9 | 23G2 | 19 | 9 | 70 | 2.1 | 10 | 10 | 79 | 1.0 | 25 | 27 | 42 | 0.9 |
| 24-10 | 23A1 | 10 | 6 | 84 | 1.7 | 15 | 9 | 74 | 1.7 | 13 | 16 | 21 | 0.8 |
| 24-11 | Mock | 13 | 4 | 82 | 3.3 | 9 | 5 | 86 | 1.8 | 10 | 5 | 84 | 2.0 |
| 24-15 | *E11 | 11 | 4 | 84 | 2.8 | ||||||||
| 24-17 | 23A1 | 22 | 21 | 50 | 1.0 | 19 | 50 | 29 | 0.4 | 43 | 36 | 26 | 1.2 |
a
Cells were stained with fluorochrome-conjugated CD4 and CD8 MAbs, and antigen expression was measured by flow cytometry. Data are not shown for one mouse at 8 weeks and five mice at 12 weeks due to their death.