Table 4. WBC nuclei detection accuracy, specificity and sensitivity in blood smear images (n = 10).

Author	Year	Method	Accuracy (%)	Specificity (%)	Sensitivity (%)
Safuan et al. [56]	2018	Otsu thresholding and watershed marker	98.87	96.87	99.1
Huang et al. [57]	2012	Otsu thresholding	98	-	-
Danyali et al. [58]	2015	Fuzzy divergence threshold	98
Manik et al. [59]	2016	Adaptive thresholding	98.9
Li et al. [60]	2016	Dual thresholding	97.85
Wang et al. [61]	2106	Spectral and morphologic	90
Negm et al. [62]	2018	K-mean clustering	99.15	99.52	99.34
Khosroseresliki et al. [45]	2017	Simple thresholding	93.7	-	-
Bouchet et al. [46]	2019	Fuzzy set algorithm	99.3	-	-
Jha et al. [47]	2019	Hybrid model based on Mutual Information	98.7	98	98