Extended Data Fig. 2. Polygenicity and genetic correlation for MDD, CVD, and risk factors.
a, Heatmap of the genetic correlations between MDD, the CVDs, and the risk factors, with the color indicating the effect direction (negative: red, positive: blue) and the size and shade of the square illustrating the size of the correlation. Results are based on LD Score Regression analysis. b, Polygenicity estimates from SBayesS (y-axis) and MiXeR (x-axis) for MDD, the CVDs, and the risk factors. Note that for PAD polygenicity estimates did not converge for SBayeS, possibly because of the few number of cases. Points and error bars represent the mean number of estimated non-zero variants and 95% CIs. a, b Sample sizes for underlying GWAS summary statistics are reported in Supplementary Table 1. AF=Atrial Fibrillation; CAD=Coronary Artery Disease; Child. Mal.=Childhood Maltreatment; CRP=C-Reactive Protein; DBP=Diastolic Blood Pressure; Edu=Educational attainment; HDL=High-Density Lipoprotein; HF=Heart Failure; IL6=Interleukin-6; LDL=Low-Density Lipoprotein; MDD=Major Depressive Disorder; NonHDL=Non-High-Density Lipoprotein; PAD=Peripheral Artery Disease; Phys. Act.=Physical activity; PP=Pulse Pressure; Psychosocial=Psychosocial/lifestyle; SBP=Systolic Blood Pressure; T2D=Type II Diabetes; TC=Total Cholesterol; TG=Triglycerides.