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Elevations in on-treatment ALT and BILI values in reference to the individual subject’s pretreatment values (BLN) by treatment arm
| Analyte | Placebo n = 249 |
Study drug n = 748 |
RR (95% CI) |
% change |
|---|---|---|---|---|
| ALT > 1×BLN | 220 (88.4) | 51 (6.8) | 0.08 (0.06–0.10) | −81.6 |
| BILI > 1×BLN | 218 (87.6) | 732 (97.9) | 1.10 (1.00–1.10) | 10.3 |
ALT alanine aminotransferase, BILI total bilirubin, BLN baseline liver test value, CI confidence interval, RR risk ratio
