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Metformin pre-treatment regulated inflammatory responses in sepsis-induced mice. (A–F) The levels of pro-inflammatory cytokines (IL-1β, CCL3, CXCL11 S100A8, S100A9), and the inflammasome NLRP3 (G–I) were measured by qPCR assay, (D–F) pro-inflammatory cytokines (IL-1β, TNF-α IL-18) were examined by ELISA assay in the lung tissues. *p<0.05,**p<0.01, ***p<0.001, ****p<0.0001.
Abbreviation: ns, non-significant.
