Fig. 7.

Inhibition of OS lung metastases by GSK126 in vivo. a Luciferase imaging of mice injected with SJSA1 cells comparing day 3, when primary tumors had developed, and day 21, after primary tumors had been removed by amputation but before treatment initiation. The bottom panels shows luciferase imaging and lung tumors for mice treated with control-, vehicle (cyclodextrin)-, and EZH2 inhibitor (EZH2i; GSK126) by day 48 after the start of the regimen. b Quantification of luciferase activity. c number of tumor nodules in control-treated versus GSK126-treated mice. d Survival curves for all mice. e Weight of lungs in control- and GSK126-treated mice. F Representative images of H&E staining of explanted lungs treated with Vehicle and GSK126. Scale bar: 100 μm