Table 4.
Predictive efficacy of DCE quantitative parameters for MVI status of HCC in the training set
| Parameters | Threshold | AUC (95% CI) | Accuracy (%) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|
| Intra-tumoral region | |||||||
| ART-T (%) | 58.35 | 0.754 (0.648, 0.860) | 75.27 (70/93) | 67.74 (21/31) | 79.03 (49/62) | 61.76 (21/34) | 83.05 (49/59) |
| Fp-T (mL/min/100 g) | 70.85 | 0.774 (0.670, 0.878) | 75.27 (70/93) | 74.19 (23/31) | 75.81 (47/62) | 60.53 (23/38) | 85.45 (47/55) |
| Ft-T (mL/min/100 g) | 180.71 | 0.790 (0.692, 0.888) | 75.27 (70/93) | 80.65 (25/31) | 72.58 (45/62) | 59.52 (25/42) | 88.24 (45/51) |
| MTT-T (s) | 13.28 | 0.643 (0.521, 0.765) | 58.06 (54/93) | 77.42 (24/31) | 48.39 (30/62) | 42.86 (24/56) | 81.08 (30/37) |
| Peritumoral region | |||||||
| ART-P (%) | 28.19 | 0.792 (0.690, 0.895) | 78.49 (73/93) | 74.19 (23/31) | 80.65 (50/62) | 65.71 (23/35) | 86.21 (50/58) |
| Fa-P (mL/min/100 g) | 36.36 | 0.682 (0.569, 0.795) | 62.37 (58/93) | 87.10 (27/31) | 50.00 (31/62) | 46.55 (27/58) | 88.57 (31/35) |
| MTT-P (s) | 21.10 | 0.645 (0.534, 0.755) | 60.22 (66/93) | 87.10 (27/31) | 46.77 (29/62) | 45.00 (27/60) | 87.88 (29/33) |
Except for AUC, values are percentages with the number of examinations in parentheses
ART arterial fraction, AUC area under the curve, CI confidence interval, DCE dynamic contrast enhanced, Fa arterial blood flow, Fp portal-venous blood flow, Ft total blood flow, HCC hepatocellular carcinoma, MTT mean transit time, MVI microvascular invasion, NPV negative predictive value, P peritumoral region, PPV positive predictive value, T intra-tumoral region