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. 2024 May 6;130(12):1929–1935. doi: 10.1038/s41416-024-02700-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Shown is the comparison between the restricted-mean survival time difference (RMST-D) and the median difference in absolute (left), and relative (right) terms for the surrogate endpoints and overall survival (OS). No difference could be calculated for ORIOLE since the median was not estimable (indicated by ∞). b Correlation between RMST-D and hazard ratio (HR) is depicted, along with its associations with proportional hazards (PH) violation, sample size, histology, and outcome. OS overall survival, PFS progression-free survival, bRFS biochemical recurrence-free survival.