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. 2024 Jun 17;15:5155. doi: 10.1038/s41467-024-49486-5

Fig. 6. H3R26C mutant expressing MPC form populations after differentiation induction that are distinct from H3WT.

Fig. 6

H3WT and H3R26C expressing MPC were induced to differentiate with 5-Azacitidine (5-Aza) and transcriptionally profiled as single cells along with vehicle (DMSO) controls. A The transcriptomes of all four conditions are represented as ten clusters on a UMAP projection with relevant marker genes or linage assignments listed with the group names. The dashed line indicates Spp1+ groups, which are labeled with grey font. B The expression of individual marker genes was plotted for groups of interest and overlayed on the UMAP. C The proportion of sample (by genotype and treatment) represented in each group (source data are provided as a Source Data file) are plotted. D The sample identities are projected on the same UMAP as panel A.