Table 2.
SLEDAI-2K score descriptors grouped by organ systems (17).
| Organ System | Descriptor | Points |
|---|---|---|
| Neurological | Recent onset seizure | 8 |
| Psychosis | 8 | |
| Organic brain syndrome | 8 | |
| New onset sensory or motor neuropathy involving cranial nerves | 8 | |
| Lupus headache | 8 | |
| New onset stroke | 8 | |
| Dermatological | Inflammatory-type rash | 2 |
| Alopecia | 2 | |
| Musculoskeletal | Arthritis | 4 |
| Myositis | 4 | |
| Renal | Heme-granular or RBC urinary casts | 4 |
| Hematuria (>5 RBC/high-power field) | 4 | |
| Proteinuria (>0.5 g/24 hours) | 4 | |
| Pyuria (>5 WBC/high-power field) | 4 | |
| Cardiopulmonary | Pleuritic chest pain with pleural rub/effusion or pleural thickening | 2 |
| Pericarditis | 2 | |
| Vascular | Vasculitis | 8 |
| Ophthalmological | Visual disturbance | 8 |
| Immunological | Low complement (CH50, C3, C4 decreased below lower limit of normal for lab) | 2 |
| High DNA binding (Increased above normal range for lab) | 2 | |
| Hematological | Platelets <100 x 10^9/L | 1 |
| WBC <3 x 10^9/L | 1 | |
| Mucosal | Oral or nasal mucosal ulcers | 2 |
| General/Constitutional | Temp >100.4°F (38°C) | 1 |