Table.

Clinical results of large randomised trials

Trial	Agent	Drug name	Disease type	Primary outcome	Result on primary outcome
Jacobs et al8	Interferon beta-1a	Avonex	Relapsing-remitting	Time to confirmed progression	Positive
	Interferon beta-1a	Avonex	Secondary progressive	Time to confirmed progression	Trial still ongoing
	Interferon beta-1a	Avonex	After first attack	Time to second attack	Presented as positive; not yet published
	Interferon beta-1a	Avonex	Primary progressive	Time to confirmed progression	Trial still ongoing
The PRISMS Study Group9	Interferon beta-1a	Rebif	Relapsing-remitting	Relapse rate	Positive
The SPECTRIMS study	Interferon beta-1a	Rebif	Secondary progressive	Time to confirmed progression	Presented as negative; not yet published
Comi et al15	Interferon beta-1a	Rebif	After first attack	Time to second attack	Trial terminated; not yet published
The INFB Multiple Sclerosis Study Group10	Interferon beta-1b	Betaferon*	Relapsing-remitting	Relapse rate	Positive
European Study Group19	Interferon beta-1b	Betaferon*	Secondary progressive	Time to confirmed progression	Positive
	Interferon beta-1b	Betaferon*	Secondary progressive	Time to confirmed progression	Presented as negative; not yet published
Johnson et al11	Glatiramer acetate	Copaxone	Relapsing-remitting	Relapse rate	Positive

^*Betaseron in United States.