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. 2024 Jun 17;10(2):e004315. doi: 10.1136/rmdopen-2024-004315

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Overall disease activity (pVAS) at diagnosis in paediatric-onset small vessel vasculitis stratified by ANCA status. A linear regression model adjusted for age at the time of diagnosis and sex was used to compare overall disease activity, quantified using the total pVAS (y-axis), at diagnosis in n=398 children and adolescents with small vessel vasculitis (x-axis) stratified according to the absence (ANCA -, n=40) or presence (ANCA +, n=358) of ANCA as well as specificity of ANCA towards MPO (MPO-ANCA, n=126) and PR3 (PR3-ANCA, n=232). Data are presented as boxplots showing the median (solid line) and IQR. See online supplemental table S1 for mean differences. ANCA, anti-neutrophil cytoplasmic antibody; MPO, myeloperoxidase; pVAS, paediatric Vasculitis Activity Score.