Figure 2.

(a) Association between the cumulative incidence of time to composite end point and time-varying severe metabolic acidosis (red line), mild-to-moderate metabolic acidosis (blue line), and no acidosis (green line). (b) Association between the degree of time-varying metabolic acidosis and time to composite end point. Number at risk in Figure 2a and b corresponds to the number of patients with available HCO₃⁻ at a given time point. CI, confidence interval; HCO3⁻, serum bicarbonate concentration; HR, hazard ratio.