Figure 5.

The NFYC signaling molecule network and annotated drug targets in patients with active lupus nephritis. Genes in the plasma cells, Ig gene module were imputed in iRegulon through Cytoscape to generate signaling molecule networks and identify their chief regulators. One of the most enriched signaling molecule networks, based on normalized enrichment score, is plotted, with the chief regulator NFYC in the central node. The color of the nodes ranges from light blue (downregulated genes) to increasing intensities of red (upregulated genes) based on the gene dysregulation (z-scores) in the lo-IFN patient subgroup. Inhibiting drugs and their upregulated targets are indicated by colored dots. IFN, interferon; lo, low; NFYC, nuclear transcription factor Y subunit gamma.