Table 1.
Summary of in vitro IC50 values from cell-viability assays and clonogenic assays
| ADC | Cell viability assays IC50 (pM) |
CFU assays IC50 (pM) |
||||||
|---|---|---|---|---|---|---|---|---|
| Jurkat (hCD45+) |
OCIM1 (hCD45+) |
293T (hCD45−) |
||||||
| Average | n | Average | n | Average | n | Average | n | |
| Isotype-SG3249 | 309.6 | 4 | 214.4 | 4 | >6,000 | 3 | 17,131.92 | 6 |
| Isotype-SG3376 | 3,399.8 | 4 | 2,288.3 | 4 | >6,000 | 3 | >100,000.00 | 3 |
| YTH24.5-SG3249 | 0.213 | 4 | 0.030 | 4 | >6,000 | 3 | 10.16 | 6 |
| YTH24.5-SG3376 | 0.052 | 4 | 0.096 | 4 | >6,000 | 3 | 4.92 | 3 |
Mean IC50 values were determined from at least three independent experiments or from at least three normal CD34+ donors assayed in triplicate.