In vitro cytotoxic activity (IC50) and selective indices (SI) values of the ligand and its complexes (C1–C3) against WI38, HeLa, and MCF7 cell lines for 24 and 48 h.
| Compound no. | In vitro cytotoxicity IC50 (μM) and selective indices values | ||||
|---|---|---|---|---|---|
| WI38 | HeLa | SI | MCF7 | SI | |
| 24 h | |||||
| HL | 71.11 ± 3.4 | 61.62 ± 3.1 | 1.15 | 40.83 ± 2.6 | 1.74 |
| (C1) | 57.22 ± 2.8 | 10.77 ± 0.9 | 5.31 | 19.47 ± 1.5 | 2.94 |
| (C2) | 29.51 ± 2.2 | 8.12 ± 0.7 | 3.63 | 12.33 ± 0.9 | 2.39 |
| (C3) | 75.42 ± 3.6 | 39.08 ± 2.5 | 1.93 | 58.79 ± 2.9 | 1.28 |
| Std. | 25.56 ± 2.1 | 34.58 ± 1.63 | 0.74 | 31.2 ± 1.8 (ref. 84) | 0.82 |
| 48 h | |||||
| HL | 74.98 ± 3.5 | 47.57 ± 2.9 | 1.57 | 36.78 ± 2.4 | 2.03 |
| (C1) | 45.24 ± 2.7 | 9.79 ± 0.8 | 4.62 | 13.40 ± 0.9 | 3.37 |
| (C2) | 31.28 ± 2.2 | 6.31 ± 0.4 | 4.95 | 8.61 ± 0.6 | 3.63 |
| (C3) | 63.60 ± 3.3 | 32.52 ± 2.3 | 1.95 | 54.04 ± 3.0 | 1.66 |
| Cisplatin | 26.68 ± 2.2 | 67.6 ± 2.0 (ref. 85) | 0.39 | 72.38 ± 0.1 (ref. 86) | 0.36 |