Table 2.
Diagnostic performance for detecting STAS using FS slides
| Cohort | GS-STAS+ (%) | FS-STAS+ (%) | STAS diagnostic performance using frozen sections |
||||
|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | PPV | NPV | Accuracy | |||
| Total (n = 114) | 43 (38%) | 43 (38%) | 81% | 89% | 81% | 89% | 86% |
| Primary LC (n = 84) | 31 (37%) | 34 (40%) | 90% | 89% | 82% | 94% | 89% |
| Metastatic tumor (n = 30) | 12 (40%) | 9 (30%) | 58% | 89% | 78% | 76% | 77% |
GS-STAS+ is the designation for positive STAS status as determined by the GS analysis using permanent slides in a consensus meeting of 3 pathologists. FS-STAS + reflects STAS detection as determined by the cryo-embedding FS technique. GS, Gold standard; STAS, spread through air spaces; FS, frozen section; PPV, positive predictive value; NPV, negative predictive value; LC, lung cancer.