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. Author manuscript; available in PMC: 2024 Jun 18.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2023 Dec 10;118(5):1228–1239. doi: 10.1016/j.ijrobp.2023.11.032

Fig. 2.

Fig. 2.

EP-3533 detects progressive radiation-induced lung injury (RILI) in a murine model. (A) Change in contrast-to-noise ratio (ΔCNR) versus time curves show progressively increased EP-3533-enhanced magnetic resonance signal at 3 months and 6 months after irradiation. (B) ΔCNR at 40 minutes postinjection is progressively elevated from 0 months, 3 months, and 6 months after irradiation. (C) Area under the curve quantification also demonstrated similar elevations in EP-3533 signal. (D-F) Validated techniques used to quantify RILI include hydroxyproline (D), collagen proportional area (E), and Ashcroft score (F). Each technique demonstrates increasing severity of RILI over time postirradiation with analysis of variance and Bonferroni post hoc t test. (G-I) Associations between EP-3533 and hydroxyproline (G), collagen proportional area (H), and Ashcroft score (I) were assessed via Pearson correlation, and EP-3533 was significantly correlated with RILI severity in each (*P < .05, **P < .001, ***P < .0001).