Figure 1.
Synthesis and evaluation of two semisynthetic vaccine candidates targeting the capsular polysaccharide, glucuronoxylomannan (GXM), of C. neoformans. (a) Structure of motif 2 of GXM and the decasaccharide antigen. (b) Conjugation of glycan 1 to carrier proteins anthrax PA63 or CRM197. (c) Immunization schedule.