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Challenge experiments with DECA-CRM197 conjugates against two strains of C. neoformans. (a) H99 challenge and (b) KN99-α challenge, in parentheses, is the median survival time. (c) Lung and brain fungal burden at day of the mouse death via CFU for H99. (d) Lung and brain fungal burden at day of the mouse death via CFU for KN99-α challenge. Shown is the median with individual points showing CFU per tissue/mouse.
