Table 3. Antischistosomal Activity of Gallinamides against Ex VivoS. mansoni Adults.

	severity scoresa
time (h)	2				6				24				48
compound (μM)	1	2	5	10	1	2	5	10	1	2	5	10	1	2	5	10
gallinamide A	0	0	0	0	0	0	0	0	0	0	0	1	0	2	2	3
1	0	0	0	0	0	0	0	1	0	0	0	4	0	2	2	4
6	0	0	1	2	0	0	1	2	0	0	2	4	0	1	4	4
9	0	0	1	1	0	0	1	2	0	0	2	4	0	2	4	4

^aPhenotypic changes in adult S. mansoni induced by compounds at given concentrations were observed and converted to severity scores on a scale of 0 (no effect) to 4 (severe effects) as described previously.^39,42,43 Data are shown as a heat map. The full phenotypic details are presented in Table S3. Compounds were tested in duplicate in two independent assays, and representative data are shown.