Table 2. Peptide Designations, Antimicrobial Activity, and Toxicity of Peptides (μM).
| peptide designation and sequencea | length | net charge | mol. Wt | E. coli (ATCC 25922) | S. aureus (ATCC 6538P) | LC50 macrophages RAW 264.7 |
|---|---|---|---|---|---|---|
| K2(AL)8K2 | 20 | +5 | 2003 | >100 | >100 | >100 |
| K2(AV)8K2 | 20 | +5 | 1890 | >100 | >100 | 90 |
| (AL)9K2 | 20 | +3 | 1931 | >100 | >100 | >100 |
| K(AL)9K | 20 | +3 | 1931 | >100 | >100 | >100 |
| L(AL)9K | 20 | +2 | 1916 | >100 | >100 | >100 |
| K(AL)3K(AL)2K(AL)3K | 20 | +5 | 1988 | 25 | 12.5 | 25 |
| K2(AL)5AK2 | 15 | +5 | 1522 | >100 | >100 | >100 |
| K2(AL)3K2 | 10 | +5 | 1088 | >100 | >100 | >100 |
a
All peptides are amidated at their C-termini.