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. 2024 Jun 18;22:576. doi: 10.1186/s12967-024-05400-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Mutational landscape profiling of VAF-related stratification system A Waterfall plot of the 15 genes involved in the model. B Oncogenic pathways enrichment analysis. C Signature analysis in all patients. D Signature analysis in high-score and low-score groups, respectively. E Characteristic genes of the signatures. Red bars are the characteristic genes in signature 1. Blue bars are the characteristic genes in signature 2. The red genes below are involved in the VAF-related stratification model. A p-value < 0.05 was considered statistically significant. F Correlation analysis of model score with clinical parameters using Pearson correlation analysis. Levels of significance: *: P < 0.05; **: P < 0.01; ***: P < 0.001. G Proportion of durable clinical benefit (DCB) and no durable benefit (NDB) patients between smoking and non-smoking groups. Chi-square test. H Comparison of Kaplan-Meier K–M survival curve of progression-free survival (PFS) between smoking and non-smoking groups. The p-value was calculated from log-rank test.